The eosinophlic leukemia is a rare malignant disease which needy to be differentiated
from hypereosinophilic syndrome. Even though there still be a controversy in diagnosing
this disease entity, it frequently reveals several findings suggesting a variant of chronic
myeloproliferative disease, including chromosomal abnormality.
Reported here, a case of eosinophilic leukemia terminated into lymphoblastic crisis,
which is believed to be a variant form of chronic myeloproliferative disease, in 34
year-old female patient.
The patient complained of generalzed weakness, hepatomegaly and lymphadenopathy
were noted. The white blood cell count was 27,600/㎣ of which 38% was eosinophils
without blast. The bone marrow cellularity was increased over 95% and the eosinophilic
aeries was 52% of total nucleated cells. The LAP score want 18(NL : 40-80). The
chromosome study revealed 46 XX, rec(8 : 9)(p 11 : q 11).
The therapeutic trial with steroid yielded initial response for 2 months followed by
recurrence of hypereosinophilia for which hydroxyurea was tried with response. Seven
months after diagnosis, blastic transformation of lymphoblastic type confirmed by
morphological, cytochemical studies and elevated TdT, developed.
Remission induction chemotherapy with vincristine, prednisolone, and daunorubicin
brought out complete remission. The relapse supervened 26 weeks after remission She
died of sepsis 20 months after diagnosis. 13 months after lymphoblastic transformation.
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